MORPHINE: INDICATIONS AND CONTRAINDICATIONS
Morphine is the drug of choice for moderate and severe cancer-related pain.
Opioid-sensittve and oploid-insensitive pain. Opioid analgesics are not equally effective against all types of pain. Neuropathic pain may be less sensitive than somatic and visceral pain. However, because of the wide range of doses which can be employed, the differences between morphine-sensitive and morphine-insensitive pain should be regarded as relative rather than absolute.
Contraindications-Morphine should be given with caution to patients with:

• renal impairment
• severe hepatic dysfunction
• significant pulmonary disease, including acute or severe bronchial asthma
• CNS depression from any cause, including CNS depressant drugs

Morphine intolerance and 'allergy,. A very small proportion of patients will suffer intolerable sedation or nausea which does not improve after the first few days' therapy and which cannot be attributed to other causes. These patients should be considered intolerant of morphine and changed to an alternative opioid.
Other patients present with a history of having been told they were allergic to morphine. This frequently relates to nausea or vomiting which occurred after a morphine injection was given for acute pain to an opioid naive patient. A careful history is required to determine the exact circumstances of the reaction. Given explanation, reassurance and the cover of antiemetic therapy for the first few days, most of these patients can be commenced on morphine without ill effect.
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Pain Relief/Muscle Relaxers